PEDF (Protein | Antibody | cDNA Clone | ELISA Kit)

All PEDF reagents are produced in house and quality controlled, including 10 PEDF Antibody, 39 PEDF Gene, 3 PEDF IP Kit, 3 PEDF Lysate, 3 PEDF Protein, 3 PEDF qPCR. All PEDF reagents are ready to use.

PEDF Protein (3)

    PEDF Antibody (10)

      PEDF cDNA Clone (39)

      NM_002615.4
      NM_011340.3
      NM_177927.2

      PEDF Lysate (3)

        PEDF Background

        Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.

        PEDF References

        • Ren, JG. et al., 2005, Med Hypotheses. 64 (1): 74-8.
        • Filleur, S. et al., 2009. J Cell Biochem. 106 (5): 769-75.
        • Kawaguchi, T. et al., 2010, Curr Mol Med. 10 (3): 302-11.
        • Yamagishi, SI. et al., 2010, Curr Mol Med. 10 (3): 284-91.
        • Nakamura, T. et al., 2010, Curr Mol Med. 10 (3): 312-6.

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