CD59 Matched ELISA Antibody Pair Set,Human

For the orders from outside of China: MOQ 15 plates, lead time: 2 weeks.
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CD59 Matched ELISA Antibody Pair Set,Human General Information

Product name
CD59 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human CD59
Assay range
234.38-15000 pg/mL
Materials provided
1. Capture Antibody 0.5 mg/mL of rabbit anti-Human CD59 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 12474-R015)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human CD59 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use. (Catalog: # 12474-R031)
3. Standard Each vial contains 240 ng of recombinant Human CD59. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 15000 pg/mL is recommended.
Product overview
This CD59 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CD59 . It contains Human CD59 capture antibody, Human CD59 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CD59 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

CD59 Matched ELISA Antibody Pair Set,Human Images

CD59 Matched ELISA Antibody Pair Set,Human: Synonyms

16.3A5 Matched ELISA Antibody Pair Set, Human; 1F5 Matched ELISA Antibody Pair Set, Human; EJ16 Matched ELISA Antibody Pair Set, Human; EJ30 Matched ELISA Antibody Pair Set, Human; EL32 Matched ELISA Antibody Pair Set, Human; FLJ38134 Matched ELISA Antibody Pair Set, Human; FLJ92039 Matched ELISA Antibody Pair Set, Human; G344 Matched ELISA Antibody Pair Set, Human; HRF-20 Matched ELISA Antibody Pair Set, Human; HRF20 Matched ELISA Antibody Pair Set, Human; MAC-IP Matched ELISA Antibody Pair Set, Human; MACIF Matched ELISA Antibody Pair Set, Human; MEM43 Matched ELISA Antibody Pair Set, Human; MGC2354 Matched ELISA Antibody Pair Set, Human; MIC11 Matched ELISA Antibody Pair Set, Human; MIN1 Matched ELISA Antibody Pair Set, Human; MIN2 Matched ELISA Antibody Pair Set, Human; MIN3 Matched ELISA Antibody Pair Set, Human; MIRL Matched ELISA Antibody Pair Set, Human; MSK21 Matched ELISA Antibody Pair Set, Human; p18-20 Matched ELISA Antibody Pair Set, Human

CD59 Background Information

CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
Full Name
CD59 molecule
Related Pathways
  • Complement Activation Pathways
    Complement Activation Pathways
References
  • Fletcher CM. et al., 1994, Structure. 2: 185-99.
  • Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
  • Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
  • Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
  • Picariello G. et al., 2008, Proteomics 8: 3833-47.
  • Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
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