Olig2: Olig2 Protein | Olig2 Antibody

Olig2 Gene family

Olig2 Background

Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia.

Reference for Olig2

  • Wang J, et al., 2000, Proc Natl Acad Sci. 97(7): 3497-502.
  • Lu QR, et al., 2001, Proc Natl Acad Sci. 98(19): 10851-6.
  • Marie Y, et al., 2001, Lancet. 358(9278): 298-300.

Olig2 Protein

Olig2 protein function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}.

Olig2 protein expression

Tissue specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Induction

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).

Olig2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    323.00
  • Mass (Da)
    32.00

Olig2 Antibody

There are 4 Olig2 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF. There are 4 Olig2 antibody for WB, 3 Olig2 antibody for IHC-P, 1 Olig2 antibody for ICC/IF. Among all these Olig2 antibodies, there are 1 anti-Olig2 rabbit monoclonal antibodies , 3 anti-Olig2 rabbit polyclonal antibodies . All the Olig2 anbodies are produced in house and all are in stock. Olig2 antibody customerized service is available.

Olig2 Gene

OLIG2 gene / cDNA is a protein-coding gene which located on 21q22.11. The OLIG2 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.156 organisms have orthologs with human gene OLIG2.