Neurotrophin receptors belong to growth factor receptors which consist of two different types of cell surface receptors---Trks (tyrosine protein receptor kinases) and p75, and mediate regulation of cell survival decisions and neuronal plasticity by neurotrophins. The p75 receptor participates with the TrkA receptor in the formation of high-affinity nerve growth factor-binding sites to promote survival under limiting concentrations of neurotrophins. The p75 receptor, a member of the TNF receptor superfamily, can induce cell death. Nerve growth factor (NGF) specifically recognizes Trk, a receptor identified in all major NGF targets, including sympathetic, trigeminal, and dorsal root ganglia as well as in cholinergic neurons of the basal forebrain and the striatum.
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