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小鼠 Thrombopoietin/THPO  基因

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Thrombopoietin/THPO 相关研究领域

Thrombopoietin/THPO 相關信號通路

    Thrombopoietin/THPO 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Thrombopoietin/THPO 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    Thrombopoietin/THPO 概述&蛋白信息

    Thrombopoietin/THPO 相關資訊

    Thrombopoietin/THPO 研究背景

    基因概述: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene
    General information above from NCBI
    結構域: Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
    亞細胞定位: Secreted.
    相關疾病 : DISEASE: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the EPO/TPO family. {ECO:0000305}.
    General information above from UniProt

    Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.

    Thrombopoietin/THPO 別稱

    Thrombopoietin/THPO 相關文獻

  • Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
  • Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?
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