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小鼠 ILK / Integrin Linked Kinase  蛋白

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ILK / Integrin Linked Kinase

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ILK / Integrin Linked Kinase 相关研究领域

ILK / Integrin Linked Kinase 相關信號通路


ILK / Integrin Linked Kinase 相關蛋白、抗體、cDNA基因、ELISA試劑盒

ILK / Integrin Linked Kinase 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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ILK / Integrin Linked Kinase 概述&蛋白信息

ILK / Integrin Linked Kinase 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
酶調控: ENZYME REGULATION: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.
亞單位結構: Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1. {ECO:0000250, ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:12167643, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:19074270, ECO:0000269|PubMed:19117955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:20117114}.
結構域: A PH-like domain is involved in phosphatidylinositol phosphate binding. {ECO:0000269|PubMed:19074270, ECO:0000269|PubMed:19117955}.
亞細胞定位: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.
組織特異性: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
翻譯後修飾: Autophosphorylated on serine residues.
相似的序列: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. {ECO:0000305}.; Contains 5 ANK repeats. {ECO:0000255|PROSITE-ProRule:PRU00023}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

ILK / Integrin Linked Kinase 別稱

ILK-1,ILK-2,p59ILK,HEL-S-28,p59, [homo-sapiens]
ESTM24,AA511515, [mus-musculus]

ILK / Integrin Linked Kinase 相關文獻

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