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小鼠 IL-F3/ILF3  基因

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IL-F3/ILF3 相关研究领域

IL-F3/ILF3 相關信號通路

    IL-F3/ILF3 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    IL-F3/ILF3 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    IL-F3/ILF3 概述&蛋白信息

    IL-F3/ILF3 研究背景

    亞單位結構: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:11777942, ECO:0000269|PubMed:14570900, ECO:0000269|PubMed:15254228, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17890166, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:9442054}.
    亞細胞定位: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
    組織特異性: Ubiquitous.
    翻譯後修飾: Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication. {ECO:0000269|PubMed:21123651}.; Methylated by protein arginine N-methyltransferase 1.; Arg-609 is dimethylated, probably to asymmetric dimethylarginine.
    相似的序列: Contains 2 DRBM (double-stranded RNA-binding) domains. {ECO:0000255|PROSITE-ProRule:PRU00266}.; Contains 1 DZF domain. {ECO:0000255|PROSITE-ProRule:PRU01040}.
    General information above from UniProt

    IL-F3/ILF3 別稱

    CBTF,DRBF,MMP4,MPP4,NF90,NFAR,NF110,NF90a,NF90b,NFAR2,TCP80,DRBP76,NF110b,NFAR-1,TCP110,MPHOSPH4,NF-AT-90, [homo-sapiens]
    NF90,NFAR,MBII-26,MPHOSPH4, [mus-musculus]

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