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小鼠 IL9R  基因

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IL9R 相关研究领域

IL9R 相關蛋白、抗體、cDNA基因、ELISA試劑盒

IL9R 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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IL9R 概述&蛋白信息

IL9R 研究背景

基因概述: The protein encoded by this IL9R gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9R complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This IL9R gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene.
General information above from NCBI
結構域: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
亞細胞定位: Cell membrane; Single-pass type I membrane protein. Secreted.
相似的序列: Belongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}.; Contains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.
General information above from UniProt

IL9R 別稱

CD129,IL-9R, [homo-sapiens]
interleukin-9 receptor,Rattus norvegicus, [human]

IL9R 相關文獻

  • Demoulin JB. et al. (1998) Interleukin 9 and its receptor: an overview of structure and function. Int Rev Immunol. 16 (3-4): 345-64.
  • Sliva D. et al. (1999) Tip60 interacts with human interleukin-9 receptor alpha-chain. Biochem Biophys Res Commun. 263 (1): 149-55.
  • Renauld JC. et al. (1995) Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis. J Leukoc Biol. 57 (3): 353-60.
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