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小鼠 IL5RA (CD125)  基因

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IL5RA (CD125)

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IL5RA (CD125) 相关研究领域

IL5RA (CD125) 相關信號通路

IL5RA (CD125) 相關蛋白、抗體、cDNA基因、ELISA試劑盒

IL5RA (CD125) 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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IL5RA (CD125) 概述&蛋白信息

IL5RA (CD125) 相關資訊

IL5RA (CD125) 研究背景

基因概述: The IL5RA protein encoded by this IL5RA gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
General information above from NCBI
亞單位結構: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP. {ECO:0000269|PubMed:12842047, ECO:0000269|PubMed:22153509}.
結構域: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
亞細胞定位: Membrane; Single-pass type I membrane protein.
組織特異性: Expressed on eosinophils and basophils.
相似的序列: Belongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
General information above from UniProt

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine which is particularly important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors.

IL5RA (CD125) 別稱

IL5R,CD125,CDw125,HSIL5R3, [homo-sapiens]
CDw125,CD125,HSIL5R3,IL5R,IL5RA,MGC26560, [human]
CDw125,CD125,Il5r,Il5ra, [mouse]
Il5r,CD125,CDw125, [mus-musculus]

IL5RA (CD125) 相關文獻

  • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.
  • Cheong HS, et al. (2005) Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. J Hum Genet. 50(12): 628-34.
  • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.
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