MAPKAPK3 (Protein | Antibody | cDNA Clone | ELISA Kit)

All MAPKAPK3 reagents are produced in house and quality controlled, including 2 MAPKAPK3 Antibody, 30 MAPKAPK3 Gene, 1 MAPKAPK3 Lysate, 1 MAPKAPK3 Protein, 2 MAPKAPK3 qPCR. All MAPKAPK3 reagents are ready to use.

MAPKAPK3 Protein (1)

    MAPKAPK3 Antibody (2)

      MAPKAPK3 cDNA Clone (30)

      MAPKAPK3 Lysate (1)

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        MAPKAPK3 Related Research Area

        MAPKAPK3 Background

        The MAPKAP kinases are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is Widely expressed in human tissues, with a higher expression level observed in heart and skeletal muscle. No expression in brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines, and translocates to the cytoplasm from nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however the mechanism defining the specificity remains unknown.

        MAPKAPK3 References

        • McLaughlin, M.M. et al., 1996, J. Biol. Chem. 271:8488-8492.
        • Tanoue, T. et al., 2001, EMBO J. 20: 466-479.
        • Neufeld, B. et al., 2000, J. Biol. Chem. 275: 20239-20242.
        • Zakowski,V. et al., 2004, Exp Cell Res. 299: 101-109.
        • Voncken, J. W. et al., 2005, J. Biol. Chem. 280: 5178-5187.