IL-20 (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL-20 reagents are produced in house and quality controlled, including 6 IL-20 Antibody, 2 IL-20 ELISA, 28 IL-20 Gene, 1 IL-20 IP Kit, 2 IL-20 Protein, 3 IL-20 qPCR. All IL-20 reagents are ready to use.

IL-20 Protein (2)

IL-20 Antibody (6)

IL-20 ELISA Kit & Match Antibody ELISA Pair Set (2)

IL-20 cDNA Clone (28)

BC069311

In expression vector

In lentiviral vector

NM_001143881.1

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IL-20 Background

IL2/Interleukin-2 belongs to the IL-1 family. It is a cytokine structurally related to interleukin 1. IL2/Interleukin-2 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-2 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL2/Interleukin-2 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

IL-20 References

  • Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
  • Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
  • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.