Interleukin-1 Receptor

Interleukin-1 receptor (IL-1R) is a protein that binds to interleukin-1. There are two forms of IL-1R: the type I receptor (IL-1RI) is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptor (IL-1RII) may act as a suppressor of IL-1 activity by competing for IL-1 binding. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin-1 receptor (IL-1RI) has three immunoglobulin-like domains. The first and second immunoglobulin domains form a conserved binding site, and its third domain shows flexibility within a certain range. IL-1, IL-1R and IL-1 receptor accessory protein (IL1RAP) form a functional signaling receptor complex, which triggers downstream signaling pathways to produce physiological responses.

interleukin-1 receptor

Interleukin-1 Receptor Products List

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IL1R1/IL-1R1/IL-1 RI IL-1R2/CD121b IL-1RAcP/IL-1R3
IL-1R8/IL1RAPL1 IL-1R9/IL1RAPL2 IL18R1
IL18RAP IL1RL1/IL-1 R4 IL1RL2/IL1RRP2
SIGIRR/TIR8    
Receptors
Receptors Classification
Cytokine Receptors+
- Chemokine Receptor
- IFN Receptor
- TNF Receptor
- CSF Receptor
- Interleukin Receptor
Interleukin-1 Receptor
Interleukin-6 Receptor
Interleukin-10 Receptor
Interleukin-12 Receptor
Interleukin-17 Receptor
- TGF-beta Superfamily Receptors
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species