Growth Factor Receptors

Growth factor receptors are transmembrane proteins which bind to specific growth factors and transmit the instructions conveyed by the factors to intracellular space. The growth factor receptors on cell surface are very common, and cells mainly contains receptors for several growth factors. Most receptors have a cysteine-rich region, which participate in signal transduction by receptor tyrosine kinase, e.g., the receptors fibroblast growth factor, vascular endothelial growth factor, epidermal growth factor, insulin-like growth factor, and platelet-derived growth factor, etc. Meanwhile, there are some receptors which mediate the signal transduction via receptor serine-threonine kinase, such as the receptor for transforming growth factor β.

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