GDNF receptors and their cognate ligands are now recognized as one of the major neurotrophic networks in the nervous system, important for the development, maintenance and function of a variety of neurons and glial cells. As members of TGF-beta superfamily receptors, GDNF receptors take part in the control of multiple types of processes, from neuronal survival to axon guidance and synapse formation in the developing nervous system, to synaptic function and regenerative responses in the adult.
GDNF interacts to a multi-component receptor complex compound by ligand binding cell surface component GDNF receptor alpha1 (GFRα1) and signaling component rearranged during transfection (RET) receptor tyrosine kinase.
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|NCAM1 / CD56||NCAM2 / Neural cell adhesion molecule|