Genetic Variations of Enterovirus 71 (EV71)

The molecular genotyping and epidemiological surveillance of enterovirus 71 / EV71 is conducted by detecting viral VP1. Up to now, three genotypes of enterovirus 71 / EV71 are identified, including genotype A, B and C. Moreover, genotype B can be classified into 5 sub-genotypes, named from B1 to B5; and genotype C also contains 5 sub-genotypes, which are C1 to C5. The outbreak of enterovirus 71 / EV71 appears frequently in the Asia-Pacific region since 1997, and countries such as Malaysia, Singapore, Japan, mainland China, and Taiwan are seriously affected, where sub-genotypes B5 and C4 are found.

In mainland China, sub-genotype C4 is predominant in enterovirus 71 / EV71 infection, and it reached Guangdong province in 1998. Enterovirus 71 / EV71 epidemics is initially restricted to the south of China, nevertheless, it has been expanded to the other areas since 2004. Epidemics of HFMD associated with EV71-associated neurological syndrome have been reported in Anhui, Shandong, Shanghai, and Beijing; meanwhile, there have been sporadic HFMD cases in other provinces. In 2008, 488,955 HFMD cases have been confirmed nationwide, of which 126 are fatal cases.

Table 1. Distribution of EV71 genotypes throughout the world from 1997 to 2010

What is Enterovirus 71 (EV71)? Biological Characteristics of Enterovirus 71 (EV71)
Genetic Variations of Enterovirus 71 (EV71) Clinical Development of Enterovirus 71 (EV71) Vaccine
Potential Drug Targets of Enterovirus 71 (EV71)  
EV71 Virus Protein

Enterovirus VP0 Protein & Antibody

EV71 Strain Source

Strain BrCr

EV71 Infection Receptor

CyPA / PPIA
Vimentin / VIM
FABP1 / L-FABP
FABP2 / I-FABP
hnRNP K / HNRNPK
PSGL-1 / CD162
SCARB2 / LAMP-2

EV71 Information

What is Enterovirus 71 (EV71)
Biological Characteristics of Enterovirus 71 (EV71)
Genetic Variations of Enterovirus 71 (EV71)
Clinical Development of Enterovirus 71 (EV71)
Potential Drug Targets of Enterovirus 71 (EV71)

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