Fibroblast Growth Factor Receptor/FGF Receptor

Fibroblast growth factor receptors (FGF receptors) are single-pass membrane proteins, with N-terminal extracellular (EC) domains consisting of three immunoglobulin-like domains (Ig 1, Ig 2 and Ig 3), a transmembrane (TM) domain consisting of a single α-helix, and an intracellular (IC) region encompassing a tyrosine kinase domain.

Upon ligand binding, FGF receptor, members of growth factor receptors, induces intracellular signaling networks that tightly regulates key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGF receptor signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGF receptors have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications.

fgf receptor

FGF Receptor Products List

* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.

FGFR1/CD331 FGFR2/CD332 FGFR3/CD333
FGFR4/CD334 FGFRL1/FGFR5 FOP/FGFR1OP
Receptors
Receptors Classification
What are Receptors
Cytokine Receptors
Growth Factor Receptors+
- Wnt Receptor
- Tie Receptor
- Neurotrophin Receptor
- Ephrin Receptor/Eph Receptor
- Insulin-Like Growth Factor Receptor/IGF Receptor
- Epidermal Growth Factor Receptor/EGF Receptor
- Fibroblast Growth Factor Receptor/FGF Receptor
- Platelet-Derived Growth Factor Receptor/PDGF Receptor
- Vascular Endothelial Growth Factor Receptor/VEGF Receptor
Fc Receptor / FcR
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species