FGF21 (Protein | Antibody | cDNA Clone | ELISA Kit)

All FGF21 reagents are produced in house and quality controlled, including 3 FGF21 Antibody, 39 FGF21 Gene, 1 FGF21 Lysate, 2 FGF21 Protein, 2 FGF21 qPCR. All FGF21 reagents are ready to use.

FGF21 Protein (2)

    FGF21 Antibody (3)

      FGF21 cDNA Clone (39)

      NM_019113.2
      NM_020013.4
      XM_541510.2

      FGF21 Lysate (1)

        FGF21 Background

        Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

        FGF21 References

        • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
        • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
        • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.

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