Fc epsilon receptor / FCER / FcεR

Fc epsilon receptor definition

Fc epsilon receptor (FcεR) is the Fc receptor that binding IgE. There are two classes of FcεRs on cells of the immune system. The high-affinity receptor, FcεRI, which is capable of binding monomeric IgE. The low-affinity receptor, FcεRII (CD23), which interacts preferentially with complex IgE.

Fc epsilon receptor I (FcεRI)

Fc epsilon receptor I is found on epidermal Langerhans cells, eosinophils, mast cells and basophils. The classical Fc epsilon receptor I is tetrameric. It consists of a α-chain which provides the binding site for IgE, β-chain and nomodimeric γ-chain. The β-chain of Fc epsilon receptor I enhances receptor maturation and leads to an increase of FcεRI surface expression and signal transduction capacity within the cells. The γ-chain subunits are responsible for transducing the initial signal into the cells. Fc epsilon receptor I is involved in allergic reactions and defense against parasitic infections. When an appropriate allergic antigen or parasite is present, the cross-linking of a least two of IgE molecules and their Fc receptors on the surface of a granulocyte will trigger the cell to rapidly release preformed mediators from its granules.

Fc epsilon receptor II (FcεR II)

Most Fc epsilon receptor II are found in B lymphocytes. Fc epsilon receptor II has multiple functions as a membrane-bound or soluble receptor. Fc epsilon receptor II controls B cell growth and differentiation and blocks IgE-binding of eosinophils, monocytes and basophils.

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Fc Receptor

Fc receptor Information

What is Fc receptor
Fc receptor function
Classes of Fc receptor

    --Fc alpha receptor (FCAR / FcαR)
    --Fc gamma receptor (FCGR / FcγR)
    --Fc epsilon recepto (FCER / FcεR)
    --Neonatal Fc receptor (FCGRT)
    --Fc Receptor-Like protein (FCRL / FCRH)
    --Fcα/μR (FCAMR)

Fc Receptor Reagents

CD16 / FCGR3
CD16-2/FCGR4
CD16a / FCGR3A
CD16b / FCGR3B
CD23 / FCER2
CD32a / FCGR2A
CD32b / FCGR2B
CD64 / FCGR1
CD89 / FCAR
FCAMR
FCER1G
FcERI / FCER1A
FCGRT
FCGRT & B2M
FCRL1 / FCRH1
FCRL3
FCRL4