Ephrin A2 / EFNA2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Ephrin A2 / EFNA2 reagents are produced in house and quality controlled, including 2 Ephrin A2 / EFNA2 Antibody, 27 Ephrin A2 / EFNA2 Gene, 3 Ephrin A2 / EFNA2 Lysate, 3 Ephrin A2 / EFNA2 Protein, 2 Ephrin A2 / EFNA2 qPCR. All Ephrin A2 / EFNA2 reagents are ready to use.

Ephrin A2 / EFNA2 Protein (3)

    Ephrin A2 / EFNA2 Antibody (2)

      Ephrin A2 / EFNA2 cDNA Clone (27)

      NM_001405.3

      In expression vector

      NM_007909.3
      NM_001168670.1

      Ephrin A2 / EFNA2 Lysate (3)

        Ephrin A2 / EFNA2 Background

        Ephrin-A2 also known as EFNA2 or EPH-related receptor tyrosine kinase ligand 6, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A2 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A2 regulates the position-specific affinity of limb mesenchyme and is involved in cartilage pattern formation in the limb.

        Ephrin A2 / EFNA2 References

        • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
        • Jurney WM, et al. (2002) Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse. J Neurosci. 22(14): 6019-28.
        • Holmberg J, et al. (2005) Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev. 19(4): 462-71.

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