Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule, formerly known as CD66a or biliary glycoprotein 1, which belongs to the carcino- embryonic antigen family and a subgroup of the immunoglobu- lin (Ig) superfamily. CEACAM1 is known to be a tumor suppressor, which acts as a regulator of apoptosis. The expression of CEACAM1 is downregulated in malignant tissues derived from colon, breast, prostate and endometrium. On the other hand, upregulation of CEACAM1 is associated with a short survival and metastatic spread in patients with cutaneous malignant melanoma and in lung cancer.
Ieda J, Yokoyama S, Tamura K, et al. Re‐expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer[J]. International Journal of Cancer, 2011, 129(6): 1351-1361.