Cluster of Differentiation 86 (CD86, also known as B7-2) residing on antigen-presenting cells is a co-stimulatory molecule. It is important for autoimmunity, transplantation, and cancer immunity. Variation of CD86 may make the immune cells dysfunctional and cause subsequent systemic inflammatory responses. CD86 functions as a key mediator of the activation of T cell in immune response. Lack of CD86 could lead to T cell inactivation and nonresponse to tumor cells, and thereby allows malignant progression of cancer.
Geng P, Zhao X, Xiang L, et al. Distinct Role of CD86 Polymorphisms (rs1129055, rs17281995) in Risk of Cancer: Evidence from a Meta-Analysis. Coleman WB, ed. PLoS ONE. 2014;9(11):e109131.