The expression of B7-H3 in human tumor cells is positively correlated with the degree of disease malignancy, and B7-H3 participates in the process of tumor cell immune escape. B7-H3 is highly expressed in many types of solid tumors, such as prostate cancer, pancreatic cancer, breast cancer, and gastric cancer. Previous studies demonstrated a relationship between the expression of B7-H3 and poor prognosis in cancer patients[5,8,9]. The expression of B7-H3 is also closely related to colorectal cancer (CRC). Expression of B7-H3 not only has a negative relationship with prognosis in CRC and the number of T cells in the tumor microenvironment but also is positively correlated with invasion and metastasis in CRC.
Zhang T, Jiang B, Zou S-T, Liu F, Hua D. Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World Journal of Gastroenterology?: WJG. 2015;21(6):1804-1813.