DPP2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All DPP2 reagents are produced in house and quality controlled, including 10 DPP2 Antibody, 2 DPP2 ELISA, 28 DPP2 Gene, 2 DPP2 Lysate, 2 DPP2 Protein, 2 DPP2 qPCR. All DPP2 reagents are ready to use.

DPP2 Protein (2)

DPP2 Antibody (10)

DPP2 ELISA Kit & Match Antibody ELISA Pair Set (2)

DPP2 cDNA Clone (28)

NM_013379.2
NM_031843.2
NM_031973.1

In cloning vector

In lentiviral vector

DPP2 Lysate (2)

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DPP2 Related Research Area

DPP2 Background

DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP1, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

DPP2 References

  • Chiravuri M, et al. (1999) A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol. 163(6):3092-9.
  • Fukasawa KM, et al. (2001) Cloning and functional expression of rat kidney dipeptidyl peptidase II. Biochem J. 353(Pt 2):283-90.
  • Fornas E, et al. (1992) Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Histol Histopathol. 7(2):163-8.