Complement System Role

Complement System Role (Proteins | Antibodies | Genes | ELISA Kits)

Complement System and Direct Interactions

Complement-Dependent Cytotoxicity/CDC Related Products

Complement System and Immune System

Complement System and Toll-like Receptors/TLRs

Complement Cascade Inhibitors

Complement System Role Background

The complement system comprises a far-reaching and vital component of innate immunity and represents one of the major effector mechanisms of the innate immune system. Discovered in 1896 by Bordet as a heat-labile component of serum, it was so named for its ability to 'complement' the antibacterial properties of antibody in the heat-stabile fraction of serum. It is now appreciated that complement is a complex network of plasma and membrane-associated serum proteins which can elicit highly efficient and tightly regulated inflammatory and cytolytic immune responses to infectious organisms (bacteria, viruses, parasites), tissue damaged by physical, chemical, or neoplastic insults, and other surfaces identified as 'nonself'.

For many years after its discovery, the role of complement system in immunity was thought to be confined to innate immune responses with no impact on adaptive immune responses, in much the same way as innate immunity, in general, was relegated to those functions of immunity that involved prevention and confinement of infection while adaptive immunity provided effectors required to clear the infection. The ability to separate the functions of the two arms of immunity was called into question as early as the 1970s, and since then the body of knowledge illustrating the interplay between the adaptive and innate wings of immunity has grown dramatically. Similarly, the ability of complement to not only affect robust innate immune responses but also to interface with and influence T- and B-cell biology and adaptive responses has become increasingly appreciated. This review attempts to summarize the roles that complement biology plays in the immune response, both in the innate detection and elimination of pathogenic infections and in the modulation of adaptive immune responses.

Complement System Role References

1. Dunkelberger J R, et al. (2010). Complement and its role in innate and adaptive immune responses. Cell research, 20(1), 34-50.
2. Arumugam T V, et al. (2004). The role of the complement system in ischemia-reperfusion injury. shock, 21(5), 401-409.
3. Anderson D H, et al. (2010). The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Progress in retinal and eye research, 29(2), 95-112.
Farsky S H, et al. (2000). Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment. Mediators of inflammation, 9(5), 213-221.

Complement System
Complement System Overview
What is Complement System
How Does Complement System Work
Complement Protein Fragment Nomenclature
Complement System Component / Protein Regulator and Receptor
Complement Component / Protein of Complement System
Complement Regulator of Complement System: RCA/CCP family
Complement Regulator of Complement System: Others
Complement Receptors of Complement System
Complement Genetic Feature
Regulator of complement activation / RCA Gene Cluster
Complement MAC Gene Cluster
Complement MHC Class III Gene Cluster
Complement Activation Pathways
Complement Activation Definition
Complement Activation Classical Pathway
Complement Activation Alternative Pathway
Complement Activation Lectin Pathway
Serine Proteases of Complement Activation Pathway
Complement System Role
Complement System and Direct Interactions
Complement System Function in Immune System
Complement-Dependent Cytotoxicity/CDC
Therapeutic Target of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System and Cancer
Complement System and Rheumatic Diseases
Complement Receptor 1 / CR1 and Alzheimer's Disease / AD
Complement System and Autoimmune Diseases
Complement System and Age-Related Macular Degeneration/AMD
Complement System and Schizophrenia
Complement System Deficiency Diseases
Classical Pathway Deficiency
Alternative Pathway Deficiency
Complement Receptor Deficiency
Mannose-Binding Lectin / MBL Pathway Deficiency
Membrane Attack Complex/MAC Deficiency
Total Complement Activity / CH50 / CH100
Complement System Structure
Complement Membrane Attack Complex/MAC
Complement Component / Protein Structure
Complement Regulator Structure
Complement Receptor Structure
Collectins and Ficolins: Humoral Lectins of the Innate Immune System
Complement System Effector Functions
Complement Mediated Opsonization
Complement Mediated Cell Lysis
Complement Mediated Phagocytosis
Complement Mediated Inflammation
Complement Mediated Chemotaxis
Complement Mediated Antibody Formation
Anti-Complement Antibody Products