Complement System and Diseases

Complement System and Diseases (Proteins | Antibodies | Genes | ELISA Kits)

Complement System and Cancer

Complement System and Alzheimer's Disease / AD

Complement System and Autoimmune Diseases

Other Related Research Areas

Complement System and Diseases Background

In the late 19th century, serum was found to contain a nonspecific heat-labile complementary principle that interacted with antibodies to induce bacteriolysis. Ehrlich and Morgan termed this factor complement.

The complement system is composed of more than 30 serum and membrane-bound proteins, all of which are needed for normal function of complement in innate and adaptive immunity. Historically, deficiencies within the complement system have been suspected when young children have had recurrent and difficult-to-control infections.

Major function of complement system is recognition and elimination of pathogens via direct killing and/or stimulation of phagocytosis. Activation of the complement system is, however, also involved in the pathogenesis of some diseases such as cancer, rheumatic diseases, Alzheimer's disease, autoimmune diseases, age-related macular degeneration and schizophrenia.

Complement System and Diseases References

1. Glass D, et al. (1976). Inherited deficiency of the second component of complement. Rheumatic disease associations. Journal of Clinical Investigation, 58(4), 853.
2. Volanakis J E, et al. (1998). The human complement system in health and disease (pp. 9-32). New York: Marcel Dekker.
3. Holers V M, et al. (2004). The alternative pathway of complement in disease: opportunities for therapeutic targeting. Molecular immunology, 41(2), 147-152.
4. Rogers J, et al. (1992). Complement activation by beta-amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences, 89(21), 10016-10020.

Complement System
Complement System Overview
What is Complement System
How Does Complement System Work
Complement Protein Fragment Nomenclature
Complement System Component / Protein Regulator and Receptor
Complement Component / Protein of Complement System
Complement Regulator of Complement System: RCA/CCP family
Complement Regulator of Complement System: Others
Complement Receptors of Complement System
Complement Genetic Feature
Regulator of complement activation / RCA Gene Cluster
Complement MAC Gene Cluster
Complement MHC Class III Gene Cluster
Complement Activation Pathways
Complement Activation Definition
Complement Activation Classical Pathway
Complement Activation Alternative Pathway
Complement Activation Lectin Pathway
Serine Proteases of Complement Activation Pathway
Complement System Role
Complement System and Direct Interactions
Complement System Function in Immune System
Complement-Dependent Cytotoxicity/CDC
Therapeutic Target of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System and Cancer
Complement System and Rheumatic Diseases
Complement Receptor 1 / CR1 and Alzheimer's Disease / AD
Complement System and Autoimmune Diseases
Complement System and Age-Related Macular Degeneration/AMD
Complement System and Schizophrenia
Complement System Deficiency Diseases
Classical Pathway Deficiency
Alternative Pathway Deficiency
Complement Receptor Deficiency
Mannose-Binding Lectin / MBL Pathway Deficiency
Membrane Attack Complex/MAC Deficiency
Total Complement Activity / CH50 / CH100
Complement System Structure
Complement Membrane Attack Complex/MAC
Complement Component / Protein Structure
Complement Regulator Structure
Complement Receptor Structure
Collectins and Ficolins: Humoral Lectins of the Innate Immune System
Complement System Effector Functions
Complement Mediated Opsonization
Complement Mediated Cell Lysis
Complement Mediated Phagocytosis
Complement Mediated Inflammation
Complement Mediated Chemotaxis
Complement Mediated Antibody Formation
Anti-Complement Antibody Products