Complement System and Direct Interactions

Complement System and Direct Interactions (Proteins | Antibodies | Genes | ELISA Kits)

Complement System C1q and Direct Interactions

Complement System C4b and Direct Interactions

Complement System C5 and Direct Interactions

Complement System MBL and Direct Interactions

Complement System C4BP and Direct Interactions

Complement System C5aR and Direct Interactions

Fibrinogen and Direct Interactions

Complement System MASP and Direct Interactions

Complement System C1INH and Direct Interactions

Complement System C3 and Direct Interactions

Complement System CR3 and Direct Interactions

Complement System and Direct Interactions Background

The human complement system is a powerful player in the defense against pathogenic organisms but is also critically involved in homeostasis and the mediation of immune responses. In order to exert those essential functions in immune surveillance and inflammatory triage, complement relies on an intricate interaction network between protein components, enzymes regulators and receptors. At the same time, direct interactions with components of other physiological systems drive important crosstalk mechanisms. Finally, pathogens often produce modulators that interact with complement proteins and interfere with complement function as part of their immune evasion strategies. Knowledge of the complement interaction network is therefore important for understanding the role of complement in health and disease and for the design of complement-targeted therapeutics.

Complement System and Direct Interactions References

1. Ricklin D, et al. (2013). Complement in immune and inflammatory disorders: pathophysiological mechanisms. The Journal of Immunology, 190(8), 3831-3838.
2. Ricklin D, et al. (2013). Complement in immune and inflammatory disorders: therapeutic interventions. The Journal of Immunology, 190(8), 3839-3847.
3. Ricklin D, et al. (2010). Complement: a key system for immune surveillance and homeostasis. Nature immunology, 11(9), 785-797.
4. Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. CMAP: Complement Map Database. Bioinformatics 2013 Jun 4

Complement System
Complement System Overview
Complement System Component / Protein Regulator and Receptor
Complement Genetic Feature
Complement Activation Pathways
Complement System Role
Complement System and Direct Interactions+
- Mannose Binding Lectin/MBL
Complement System Function in Immune System+
- Complement System in Adaptive Immunity
- Complement System in Innate Immunity
Complement-Dependent Cytotoxicity/CDC+
- Complement-Dependent Cytotoxicity/CDC Crossmatch
Therapeutic Target of Complement System+
- Serine Protease Inhibitors as Therapeutic Target of Complement System
- Soluble Complement Regulators as Therapeutic Target of Complement System
- Complement Component Inhibitors as Therapeutic Target of Complement System
- Anaphylatoxin Receptor Antagonists as Therapeutic Target of Complement System
- Therapeutic Antibodies of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System Deficiency Diseases
Complement System Structure
Complement System Effector Functions
Anti-Complement Antibody Products