Complement Regulator of Complement System: Others

Complement Regulator of Complement System: Others

Complement Regulator of Complement System: Others Background

The complement system is a major antimicrobial defence system in the human body. During inflammation, complement
activation products attract and activate leucocytes against their targets: bacteria, fungi and parasites. Target cells can become opsonized by complement components C3b and C4b either following deposition of antibodies (the classical pathway, CP), a carbohydrate-binding protein, mannose-binding lectin (MBL) (lectin pathway) or directly via the alternative pathway (AP). Lysis of the target is caused by the membrane attack complex of complement (MAC). The complement system also has a role in maintaining homeostasis of the host, for example by removing macromolecular aggregates and senescent endogenous cells.

Because of its strong potential for generating inflammation and causing tissue destruction, the complement system has to be kept strictly under control. Cells of the host need special protection against the products of complement lysis. Out of the 30 different glycoproteins belonging to the human complement system, 20 act in plasma and 10 are regulators or receptors on cell membranes. These molecules regulate complement activation at different steps of the complement cascade, participate in the clearance of complement-coated particles and/or protect host cells from damage. The importance of complement regulators of complement system becomes apparent in cases where their deficiency results in disease.

Complement Regulator of Complement System: Others References

1. Carroll M C. (2004). The complement system in regulation of adaptive immunity. Nature immunology, 5(10), 981-986.
2. Xu C, et al. (2000). A critical role for murine complement regulator crry in fetomaternal tolerance. Science, 287(5452), 498-501.
3. Richards A, et al. (2003). Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proceedings of the National Academy of Sciences, 100(22), 12966-12971.
4. Hellwage J, et al. (2001). The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi. Journal of Biological Chemistry, 276(11), 8427-8435.
5. Liszewski M K, et al. (1991). Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annual review of immunology, 9(1), 431-455.
6. Zipfel P F, et al. (2009). Complement regulators and inhibitory proteins. Nature Reviews Immunology, 9(10), 729-740.

Complement System
Complement System Overview
Complement System Component / Protein Regulator and Receptor
Complement Component / Protein of Complement System+
- Complement Component C1
- Complement Component C2
- Complement Component C5
- Complement Component C6
- Complement Component C7
- Complement Component C8
- Complement Component C9
- Complement Component Factor B/CFB
- Complement Component Factor D/CFD/Adipsin
- Complement Component Factor Properdin/CFP
Complement Regulator of Complement System: RCA/CCP family+
- Complement Regulator of Complement System: Decay-accelerating Factor / DAF / CD55
- Complement Regulator of Complement System: Complement Component Factor H
- Complement Regulator of Complement System: Membrane Cofactor Protein / MCP / CD46
Complement Regulator of Complement System: Others+
- Complement Regulator of Complement System: C1 Inhibitor / C1INH / SERPING1
- Complement Regulator of Complement System: Protectin / CD59
- Complement Regulator of Complement System: Vitronectin / VTN
- Complement Regulator of Complement System: Clusterin / CLU
Complement Receptors of Complement System+
- Complement Receptors of Complement System: CR1
- Complement Receptors of Complement System: CR2
- Complement Receptors of Complement System: ITGAM
- Complement Receptors of Complement System: ITGAX
- Complement C1q Receptor
- Complement Receptor of the Immunoglobulin Superfamily/CRIg
- Complement Anaphylatoxin
- Anaphylatoxin Receptors
Complement Genetic Feature
Complement Activation Pathways
Complement System Role
Complement System and Diseases
Complement System Deficiency Diseases
Complement System Structure
Complement System Effector Functions
Anti-Complement Antibody Products