Complement Genetic Feature

Regulator of Complement Activation / RCA Gene Cluster (Proteins | Antibodies | Genes | ELISA Kits)

Complement MAC Gene Cluster (Proteins | Antibodies | Genes | ELISA Kits)

Complement MHC Ⅲ Gene Cluster (Proteins | Antibodies | Genes | ELISA Kits)

Complement Genetic Polymorphism

The complement system is an important part of non clonal or innate immunity that collaborates with acquired immunity to kill pathogens and to facilitate the clearance of immune complexes. The complement is made up of 20 distinct plasma proteins and 9 different membrane proteins. Three components, factor B, C2 and C4 (with 2 isotypes), are coded by polymorphic HLA-linked genes and are sometimes referred to as MHC class III antigens, inherited as compact units called complotypes. The C4 genes are the most polymorphic, including a common null allele (Q0) at both the C4A and C4B loci. Other polymorphic complement factors (not linked to HLA) are C3 (2 common alleles), C6 and C7 (closely linked, with 3 and 2 alleles, respectively). A certain degree of polymorphism has also been described for complement receptors and membrane control proteins. No differences in functional activity are usually detected among different alleles.

Human complement C3 exhibits genetic polymorphism that was first described by Weime and Demeulenaere and Alper and Propp in 1986. The genetic variants of the protein are inherited as autosomal codominant traits and are characterized using prolonged agarose gel electrophoresis of fresh serum. In this way, two common polymorphic forms have been found, designated C3F and C3S. The C3S allele is most common in all races in humans. The C3F allele is relatively frequent in Caucasoids, less common in America Negroes, and extremely rare in Orientals. More than 20 rare allotypes have been characterized by variations in their relative electrophoretic mobilities.

Complement Genetic Feature References

1. Botto M, et al. (1990). Molecular basis of polymorphisms of human complement component C3. The Journal of experimental medicine, 172(4), 1011-1017.
2. Brai M, et al. (1993). Polymorphism of the complement components in human pathology. Annali italiani di medicina interna: organo ufficiale della Societa italiana di medicina interna, 9(3), 167-172.

Complement System
Complement System Overview
What is Complement System
How Does Complement System Work
Complement Protein Fragment Nomenclature
Complement System Component / Protein Regulator and Receptor
Complement Component / Protein of Complement System
Complement Regulator of Complement System: RCA/CCP family
Complement Regulator of Complement System: Others
Complement Receptors of Complement System
Complement Genetic Feature
Regulator of complement activation / RCA Gene Cluster
Complement MAC Gene Cluster
Complement MHC Class III Gene Cluster
Complement Activation Pathways
Complement Activation Definition
Complement Activation Classical Pathway
Complement Activation Alternative Pathway
Complement Activation Lectin Pathway
Serine Proteases of Complement Activation Pathway
Complement System Role
Complement System and Direct Interactions
Complement System Function in Immune System
Complement-Dependent Cytotoxicity/CDC
Therapeutic Target of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System and Cancer
Complement System and Rheumatic Diseases
Complement Receptor 1 / CR1 and Alzheimer's Disease / AD
Complement System and Autoimmune Diseases
Complement System and Age-Related Macular Degeneration/AMD
Complement System and Schizophrenia
Complement System Deficiency Diseases
Classical Pathway Deficiency
Alternative Pathway Deficiency
Complement Receptor Deficiency
Mannose-Binding Lectin / MBL Pathway Deficiency
Membrane Attack Complex/MAC Deficiency
Total Complement Activity / CH50 / CH100
Complement System Structure
Complement Membrane Attack Complex/MAC
Complement Component / Protein Structure
Complement Regulator Structure
Complement Receptor Structure
Collectins and Ficolins: Humoral Lectins of the Innate Immune System
Complement System Effector Functions
Complement Mediated Opsonization
Complement Mediated Cell Lysis
Complement Mediated Phagocytosis
Complement Mediated Inflammation
Complement Mediated Chemotaxis
Complement Mediated Antibody Formation
Anti-Complement Antibody Products