Complement Cascade and Inhibitors

Complement Cascade Inhibitors (Proteins | Antibodies | Genes | ELISA Kits)

Complement Cascade of Classical Pathway (Proteins | Antibodies | Genes | ELISA Kits)

Other Related Research Areas

Complement Cascade Definition

Serum complement cascade, a part of innate immunity required for host protection against invading pathogens, is also a mediator of various forms of disease and injury. It is activated by classical, lectin, and alternative pathways that lead to activation of C3 component by C3 convertases, release of C3b opsonin, C5 conversion and eventually membrane attack complex formation. The tightly regulated activation process yields also C3a and C5a anaphylatoxins, which target a broad spectrum of immune and non-immune cells.

Complement Cascade Inhibitors

The complement system, which emerged about 600-700 million years ago, constitutes an important part of the innate immune system that is designed to eliminate "harmful" substances from the body. This elimination is tightly regulated by complement cascade inhibitors. The complement cascade inhibitors include both plasma proteins factor H and C4 binding protein (C4BP) and membrane proteins primarily complement receptor type 1 (also known as CD35 or CR1), decay-accelerating factor (DAF) and membrane cofactor protein (MCP). In addition, control is also achieved through the activity of C1 inhibitor (C1-INH), carboxypeptidase N, and CD59.

Complement Cascade References

1. Kościelska-Kasprzak K, et al. (2014). The complement cascade and renal disease. Archivum immunologiae et therapiae experimentalis, 62(1), 47-57.
2. Sahu A, et al. (2000). Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics. Immunopharmacology, 49(1), 133-148.

Complement System
Complement System Overview
Complement System Component / Protein Regulator and Receptor
Complement Genetic Feature
Complement Activation Pathways
Complement System Role
Complement System and Direct Interactions+
- Mannose Binding Lectin/MBL
Complement System Function in Immune System+
- Complement System in Adaptive Immunity
- Complement System in Innate Immunity
Complement-Dependent Cytotoxicity/CDC+
- Complement-Dependent Cytotoxicity/CDC Crossmatch
Therapeutic Target of Complement System+
- Serine Protease Inhibitors as Therapeutic Target of Complement System
- Soluble Complement Regulators as Therapeutic Target of Complement System
- Complement Component Inhibitors as Therapeutic Target of Complement System
- Anaphylatoxin Receptor Antagonists as Therapeutic Target of Complement System
- Therapeutic Antibodies of Complement System
Complement System and Toll-like Receptors / TLRs
Complement System and Coagulation
Complement Cascade and Inhibitors
Complement Evasion of Pathogens
Complement System and Antimicrobial Peptides/AMPs
Complement System and Diseases
Complement System Deficiency Diseases
Complement System Structure
Complement System Effector Functions
Anti-Complement Antibody Products