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人 CTAG2 transcript variant 2 基因全長cDNA ORF(克隆載體)

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CTAG2 cdna-clone 研究背景

CAMEL (109 aa) is a tumor-specific protein translated from the LAGE-1 gene in an alternative open reading frame (ORF) starting at a second ATG start codon located 40 bp downstream of the first ATG start site. LAGE-1 shows 94% homology to tumor Ag NY-ESO-1 and both genes are located on chromosome Xp28. The LAGE-1 and NY-ESO-1 genes are frequently coexpressed in a wide variety of tumors, like melanoma, breast carcinoma, prostate and bladder cancers, but silent in normal tissues except for testis.

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 CTAG2 cdna-clone 參考資料
  • Slager E H, van der Minne C E, Krüse M, et al. Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes[J]. The Journal of Immunology, 2004, 172(8): 5095-5102.
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