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人 Vimentin / VIM 蛋白 (His 標籤)

產品資料評論實驗方法
反應性: Human  
應用 : IHC-P  
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100254-T08-50
100254-T08-200
100254-T08-100
50 µg 
200 µg 
100 µg 
Add to Cart
反應性: Human  
應用 : WB  IHC-P  
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100254-T40-50
100254-T40-200
100254-T40-100
50 µg 
200 µg 
100 µg 
Add to Cart
反應性: Human  
應用 : IHC-P  
  • Slide 1
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100254-R211-50
100254-R211-100
50 µg 
100 µg 
Add to Cart

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Vimentin protein 研究背景

Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

 Vimentin protein 參考資料
  • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
  • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
  • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”