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EpCAM / TROP-1 / TACSTD1 抗體, 鼠單抗

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10694-H08H-50
10694-H08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
10694-H02H-50
10694-H02H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50591-M08H-50
50591-M08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
80306-R08H-50
80306-R08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
80306-R02H-50
80306-R02H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90299-C02H-50
90299-C02H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90299-CCCH-50
90299-CCCH-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90299-C08H-50
90299-C08H-100
50 µg 
100 µg 
Add to Cart

EpCAM/TROP-1/TACSTD1 ELISA配對抗體

檢測限:
SEK50591-5
SEK50591-15
5 Plates 
15 Plates 
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檢測限: 46.8 pg/ml
SEK10694-5
SEK10694-15
5 Plates 
15 Plates 
Add to Cart

EpCAM/TROP-1/TACSTD1 AntibodyRelated Products

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EpCAM/TROP-1/TACSTD1 antibody 研究背景

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 EpCAM/TROP-1/TACSTD1 antibody 參考資料
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”