Text Size:AAA

NAALADL1 抗體, 兔單抗

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
11146-H07H-50
11146-H07H-20
50 µg 
20 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50937-M07H-50
50937-M07H-20
50 µg 
20 µg 
Add to Cart

NAALADL1 AntibodyRelated Products

Related Products

Featured Reagent Products

NAALADL1 antibody 研究背景

N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

小鼠 NAALADL1 antibody 參考資料
  • Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300.
  • Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15.
  • Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83.
  • Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”