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Ly108 / SLAMF6 抗體, 兔單抗

產品資料評論實驗方法
描述: Active  
表達宿主: Human Cells  
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11945-H08H-50
11945-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
11945-HCCH-50
11945-HCCH-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
11945-H02H-50
11945-H02H-100
50 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
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50275-M08H-50
50275-M08H-100
50 µg 
100 µg 
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Ly108/SLAMF6 antibody 研究背景

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

 Ly108/SLAMF6 antibody 參考資料
  • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
  • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
  • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
  • Claus M. et al., 2007, Front Biosci. 13: 956-65.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”