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NKG2D / CD314 抗體, 兔多抗, 抗原親和純化

產品資料評論實驗方法
表達宿主: CHO Stable Cells  
  • Slide 1
10575-H01S-50
10575-H01S-100
50 µg 
100 µg 
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表達宿主: Baculovirus-Insect Cells  
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10575-H07B-50
10575-H07B-100
50 µg 
100 µg 
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表達宿主: Baculovirus-Insect Cells  
  • Slide 1
90164-C07B-50
90164-C07B-100
50 µg 
100 µg 
Add to Cart

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NKG2D/CD314/KLRK1 antibody 研究背景

NKG2D, also known as CD314, is an immune receptor which consists of two disulphide-linked type II transmembrane proteins with short intracellular proteins uncapable to transduce signals. In order to transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.

 NKG2D/CD314/KLRK1 antibody 參考資料
  • Houchins J, et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med. 173: 1017-102.
  • Bauer S, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285(5428):727-9.
  • Zafirova B, et al. (2011) Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci. 68(21):3519-29.
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