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IFNAR1 抗體, 兔多抗, 抗原親和純化

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表達宿主: Human Cells  
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13222-H02H-50
13222-H02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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13222-H08H-50
13222-H08H-100
50 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
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50469-M08H-50
50469-M08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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90113-CCCH-50
90113-CCCH-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90113-C08H-50
90113-C08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
90113-C02H-50
90113-C02H-100
50 µg 
100 µg 
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IFNAR1 ELISA配對抗體

檢測限: 125 pg/ml
SEK50469-5
SEK50469-15
5 Plates 
15 Plates 
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檢測限:
SEK13222-5
SEK13222-15
5 Plates 
15 Plates 
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IFNAR1 AntibodyRelated Products

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IFNAR1 antibody 研究背景

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

 IFNAR1 antibody 參考資料
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
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