Text Size:AAA

TNFR2 / CD120b / TNFRSF1B 抗體, 兔多抗, 抗原親和純化

產品資料評論實驗方法
描述: Active  
表達宿主: Human Cells  
  • Slide 1
10417-H03H-50
10417-H03H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
10417-H08H-50
10417-H08H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
10417-H08H1-50
10417-H08H1-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
50128-M08H-50
50128-M08H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
50128-M02H-50
50128-M02H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90102-C02H-5
90102-C02H-20
90102-C02H-100
5 µg 
20 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90102-C08H-50
90102-C08H-20
50 µg 
20 µg 
Add to Cart

TNFR2/TNFRSF1B/CD120b AntibodyRelated Products

Related Products

Featured Reagent Products

TNFR2/TNFRSF1B/CD120b antibody 研究背景

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

食蟹猴 TNFR2/TNFRSF1B/CD120b antibody 參考資料
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”