Text Size:AAA

Cadherin-6 / CDH6 抗體, 兔多抗, 抗原親和純化

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10150-H08H-50
10150-H08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50985-M08H-50
50985-M08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
80277-R08H-50
80277-R08H-200
50 µg 
200 µg 
Add to Cart

Cadherin-6/CDH6 AntibodyRelated Products

Related Products

Featured Reagent Products

Cadherin-6/CDH6 antibody 研究背景

Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus , Cadherin-6 is a new prognostic factor for renal cancer.

小鼠 Cadherin-6/CDH6 antibody 參考資料
  • Paul R, et al. (1997) Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. Cancer Res. 57(13): 2741-8.
  • Paul R, et al. (2004) Cadherin-6: a new prognostic marker for renal cell carcinoma. J Urol. 171(1): 97-101.
  • Taniguchi H, et al. (2006) Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain. Development. 133(10): 1923-31.
  • Liu Q, et al. (2006) cadherin-6 message expression in the nervous system of developing zebrafish. Dev Dyn. 235(1): 272-8.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”