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PRTFDC1 抗體, 兔多抗

表達宿主: E. coli  
  • Slide 1
20 µg 
100 µg 
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PRTFDC1 antibody 研究背景

PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase. PRTFDC1 has a low, barely measurable phosphoribosyltransferase activity (in vitro).

 PRTFDC1 antibody 參考資料
  • Welin M. et al., 2010, FEBS J. 277 (23): 4920-30.
  • Keebaugh AC. et al., 2011, PLoS One. 6 (7): e22381.
  • Suzuki E. et al., 2007, Oncogene. 26 (57): 7921-32.
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