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小鼠 interleukin-20 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤

產品資料評論實驗方法
表達宿主: E. coli  
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13060-HNAE-50
13060-HNAE-20
50 µg 
20 µg 
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表達宿主: E. coli  
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80422-RNAE-50
80422-RNAE-20
50 µg 
20 µg 
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反應性: Human  
應用 : ELISA  
    13060-R017-50
    13060-R017-100
    50 µg 
    100 µg 
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    反應性: Human  
    應用 : ELISA  
      13060-RP01-400
      13060-RP01-200
      13060-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反應性: Human  
      應用 : ELISA  
        13060-MM03-50
        13060-MM03-200
        13060-MM03-100
        13060-MM03-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
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        反應性: Human  
        應用 : ELISA  
          13060-T16-50
          13060-T16-200
          13060-T16-100
          50 µg 
          200 µg 
          100 µg 
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          反應性: Human  
          應用 : 
            13060-R044-50
            13060-R044-100
            13060-R044-1
            50 µg 
            100 µg 
            1 mg 
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            反應性: Mouse  
            應用 : WB  IP  
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            100463-T36-50
            100463-T36-200
            100463-T36-100
            50 µg 
            200 µg 
            100 µg 
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            interleukin-20 cdna-clone 研究背景

            IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-20 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

            小鼠 interleukin-20 cdna-clone 參考資料
          • Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
          • Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
          • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
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