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人 Noggin/NOG 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤

產品資料評論實驗方法
描述:   
表達宿主: Human Cells  
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10267-HCCH-20
10267-HCCH-100
20 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
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10267-H02H-50
10267-H02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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10267-H08H-500
10267-H08H-5
10267-H08H-20
10267-H08H-100
10267-H08H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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表達宿主: Human Cells  
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50688-M02H-500
50688-M02H-5
50688-M02H-20
50688-M02H-100
50688-M02H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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反應性: Human  
應用 : WB  IP  
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100339-T36-50
100339-T36-200
100339-T36-100
50 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : WB  
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100339-T32-50
100339-T32-200
100339-T32-100
50 µg 
200 µg 
100 µg 
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Noggin/NOG cdna-clone 研究背景

Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.

 Noggin/NOG cdna-clone 參考資料
  • Zimmerman LB, et al. (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 86(4): 599-606.
  • Chandramore K, et al. (2010) Cloning of noggin gene from hydra and analysis of its functional conservation using Xenopus laevis embryos. Evol Dev. 12(3): 267-74.
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