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人 IGF1R / CD221 HEK293 過表達細胞裂解液 (陽性對照)

產品資料評論實驗方法
表達宿主: Baculovirus-Insect Cells  
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10164-H20B1-50
10164-H20B1-20
50 µg 
20 µg 
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描述: Active  
表達宿主: Human Cells  
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10164-H08H-50
10164-H08H-100
50 µg 
100 µg 
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反應性: Human  
應用 : FCM  
  • Slide 1
  • Slide 1
10164-R012-F-25
10164-R012-F-100
25 Test 
100 Tests 
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反應性: Human  
應用 : 
    10164-MM07-50
    10164-MM07-200
    10164-MM07-100
    10164-MM07-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    反應性: Human  
    應用 : ELISA  
      10164-RP01-400
      10164-RP01-200
      10164-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反應性: Human  
      應用 : ELISA  
        10164-R011-50
        10164-R011-100
        50 µg 
        100 µg 
        Add to Cart
        反應性: Human  
        應用 : FCM  
        • Slide 1
        • Slide 1
        10164-R012-P-25
        10164-R012-P-100
        25 Test 
        100 Tests 
        Add to Cart
        反應性: Human  
        應用 : ELISA  
          10164-MM04-50
          10164-MM04-200
          10164-MM04-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反應性: Human  
          應用 : FCM  
          • Slide 1
          10164-R012-A-25
          10164-R012-A-100
          25 Test 
          100 Tests 
          Add to Cart
          反應性: Human  
          應用 : FCM  IF  ICC/IF  
          • Slide 1
          • Slide 1
          10164-R012-50
          10164-R012-100
          50 µg 
          100 µg 
          Add to Cart
          反應性: Human  
          應用 : ELISA  
            10164-RP02-50
            10164-RP02-200
            10164-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

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            IGF1R/CD221/IGF-I R lysate_category 研究背景

            The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

             IGF1R/CD221/IGF-I R lysate_category 參考資料
          • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
          • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
          • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
          • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
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