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小鼠 IL6R/IL-6R/CD126 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

產品資料評論實驗方法
描述: Active  
表達宿主: Human Cells  
  • Slide 1
10398-H08H-50
10398-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
50280-M08H-50
50280-M08H-20
50 µg 
20 µg 
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表達宿主: Human Cells  
  • Slide 1
81072-R02H-20
81072-R02H-100
20 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
81072-R08H-50
81072-R08H-20
50 µg 
20 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
70117-D08H-5
70117-D08H-20
70117-D08H-100
5 µg 
20 µg 
100 µg 
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反應性: Human  
應用 : IF  ICC/IF  
  • Slide 1
10398-MM18-50
10398-MM18-200
10398-MM18-100
10398-MM18-1
50 µg 
200 µg 
100 µg 
1 mg 
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反應性: Human  
應用 : ELISA  
    10398-RP03-50
    10398-RP03-200
    10398-RP03-100
    50 µg 
    200 µg 
    100 µg 
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    反應性: Human  
    應用 : ELISA  
      10398-MM01-50
      10398-MM01-200
      10398-MM01-100
      50 µg 
      200 µg 
      100 µg 
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      反應性: Human  
      應用 : ELISA  
        10398-T16-50
        10398-T16-200
        10398-T16-100
        50 µg 
        200 µg 
        100 µg 
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        反應性: Human  
        應用 : ELISA  
          10398-RP01-400
          10398-RP01-200
          10398-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反應性: Human  
          應用 : B/N  
          • Slide 1
          10398-MM08-500
          10398-MM08-200
          500 µg 
          200 µg 
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          反應性: Human  
          應用 : ELISA  
            10398-RP02-400
            10398-RP02-200
            10398-RP02-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反應性: Mouse  
            應用 : FCM  
            • Slide 1
            50280-R033-A-25
            50280-R033-A-100
            25 Test 
            100 Tests 
            Add to Cart
            反應性: Mouse  
            應用 : ELISA  WB  
            • Slide 1
            50280-RP02-50
            50280-RP02-200
            50280-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反應性: Mouse  
            應用 : FCM  IF  ICC/IF  
            • Slide 1
            • Slide 1
            50280-R033-50
            50280-R033-100
            50280-R033-1
            50 µg 
            100 µg 
            1 mg 
            Add to Cart
            反應性: Mouse  
            應用 : ELISA  
              50280-R005-50
              50280-R005-100
              50 µg 
              100 µg 
              Add to Cart
              反應性: Mouse  
              應用 : ELISA  
                50280-RP01-400
                50280-RP01-200
                50280-RP01-100
                400 µg 
                200 µg 
                100 µg 
                Add to Cart
                反應性: Mouse  
                應用 : FCM  
                • Slide 1
                • Slide 1
                50280-R033-P-25
                50280-R033-P-100
                25 Test 
                100 Tests 
                Add to Cart

                IL6R/IL-6R/CD126 ELISA配對抗體

                檢測限:
                SEKA10398-5
                SEKA10398-15
                5 Plates 
                15 Plates 
                Add to Cart
                檢測限: 6.25 pg/ml
                SEK50280-5
                SEK50280-15
                5 Plates 
                15 Plates 
                Add to Cart

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                IL6R/IL-6R/CD126 cdna-clone 研究背景

                Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                小鼠 IL6R/IL-6R/CD126 cdna-clone 參考資料
              • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
              • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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