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小鼠 Ly108/SLAMF6 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

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            反應性: Mouse  
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                Ly108/SLAMF6 cdna-clone 研究背景

                SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

                小鼠 Ly108/SLAMF6 cdna-clone 參考資料
              • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
              • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
              • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
              • Claus M. et al., 2007, Front Biosci. 13: 956-65.
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