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人 G-CSF R/CD114/CSF3R transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10218-HCCH-50
10218-HCCH-100
50 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10218-H02H-50
10218-H02H-100
50 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10218-H08H-50
10218-H08H-100
50 µg 
100 µg 
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反應性: Human  
應用 : IF  ICC/IF  
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10218-MM06-50
10218-MM06-200
10218-MM06-100
10218-MM06-1
50 µg 
200 µg 
100 µg 
1 mg 
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反應性: Human  
應用 : FCM  
  • Slide 1
10218-MM06-P-25
10218-MM06-P-100
25 Test 
100 Tests 
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反應性: Human  
應用 : IF  ICC/IF  
  • Slide 1
10218-MM03-50
10218-MM03-200
10218-MM03-100
50 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : ELISA  
    10218-MM01-50
    10218-MM01-200
    10218-MM01-100
    10218-MM01-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    反應性: Human  
    應用 : FCM  
    • Slide 1
    10218-MM06-A-25
    10218-MM06-A-100
    25 Test 
    100 Tests 
    Add to Cart
    反應性: Human  
    應用 : FCM  
    • Slide 1
    10433-R048-F-25
    10433-R048-F-100
    25 Test 
    100 Tests 
    Add to Cart

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    G-CSF R/CD114/CSF3R cdna-clone 研究背景

    Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

     G-CSF R/CD114/CSF3R cdna-clone 參考資料
  • Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
  • Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
  • Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
  • Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.
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    G-CSFR/CD114 related areas, pathways, and other information

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