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VEGFR1 / FLT-1 抗體, 鼠單抗

產品資料評論實驗方法
描述: Active  
表達宿主: Human Cells  
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10136-H08H-50
10136-H08H-100
50 µg 
100 µg 
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描述:   
表達宿主: Human Cells  
  • Slide 1
10136-H08H1-50
10136-H08H1-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
10136-H02H-50
10136-H02H-20
50 µg 
20 µg 
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描述: Active  
表達宿主: Human Cells  
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80101-R08H-50
80101-R08H-100
50 µg 
100 µg 
Add to Cart

HP100207 

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VEGFR1/FLT-1 antibody 研究背景

Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains seven Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.

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 VEGFR1/FLT-1 antibody 參考資料
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