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小鼠 RhoA 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤

產品資料評論實驗方法
表達宿主: Baculovirus-Insect Cells  
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12441-H07B-50
12441-H07B-100
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反應性: Human  
應用 : FCM  
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12441-MM03-F-25
12441-MM03-F-100
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反應性: Human  
應用 : ELISA  
    12441-R101-50
    12441-R101-100
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    反應性: Human  
    應用 : FCM  
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    12441-R036-F-25
    12441-R036-F-100
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    反應性: Human  
    應用 : FCM  
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    12441-MM03-P-25
    12441-MM03-P-100
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    反應性: Human  
    應用 : ELISA  
      12441-MM09-50
      12441-MM09-200
      12441-MM09-100
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      反應性: Human  
      應用 : FCM  
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      12441-R036-50
      12441-R036-100
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      反應性: Human  
      應用 : ELISA  WB  IP  
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      12441-RP02-50
      12441-RP02-200
      12441-RP02-100
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      反應性: Human  
      應用 : ELISA  FCM  IF  ICC/IF  
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      • Slide 1
      12441-MM03-50
      12441-MM03-200
      12441-MM03-100
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      200 µg 
      100 µg 
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      反應性: Human  
      應用 : WB  IP  
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      12441-R103-50
      12441-R103-100
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      RhoA cdna-clone 研究背景

      Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein which belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP.

      小鼠 RhoA cdna-clone 參考資料
    • Kiss C, et al.,1997, Cytogenet. Cell Genet. 79 (3-4): 228-30.
    • Anastasiadis,P.Z. et al., 2000, Nat Cell Biol. 2 (9):637-44.
    • Yiu G, et al.,2006, Nat. Rev. Neurosci. 7 (8): 617-27.
    • Wang,HR. et al., 2006, Methods Enzymol. 406 :437-47.
    • Heo,J. et al., 2006, Biochemistry. 45 (48):14481-9.
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