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小鼠 Dectin-1/CLEC7A 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10215-H01H-50
10215-H01H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
10215-HNCH-50
10215-HNCH-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
10215-H04H-50
10215-H04H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
  • Slide 1
50233-M07H-50
50233-M07H-100
50 µg 
100 µg 
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反應性: Mouse  
應用 : FCM  
  • Slide 1
50233-R010-P-25
50233-R010-P-100
25 Test 
100 Tests 
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反應性: Mouse  
應用 : ELISA  
    50233-RP01-400
    50233-RP01-200
    50233-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反應性: Mouse  
    應用 : IF  ICC/IF  
    • Slide 1
    50233-R010-50
    50233-R010-100
    50 µg 
    100 µg 
    Add to Cart
    反應性: Mouse  
    應用 : ELISA  
      50233-R003-50
      50233-R003-100
      50 µg 
      100 µg 
      Add to Cart
      反應性: Mouse  
      應用 : ELISA  
        50233-RP02-50
        50233-RP02-200
        50233-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Dectin-1/CLEC7A cdna-clone 研究背景

        Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

        小鼠 Dectin-1/CLEC7A cdna-clone 參考資料
      • Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
      • Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
      • Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
      • Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
      • Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.
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