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人 MCSF Receptor/CSF1R/CD115 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤

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表達宿主: Baculovirus-Insect Cells  
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10161-H20B2-50
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表達宿主: Human Cells  
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10161-H03H-200
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表達宿主: Human Cells  
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10161-H08H-50
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表達宿主: Human Cells  
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10161-HCCH-200
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10161-H20B1-50
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表達宿主: Human Cells  
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50059-M08H-50
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表達宿主: Human Cells  
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50059-M03H-50
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表達宿主: Human Cells  
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80447-R02H-50
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表達宿主: Human Cells  
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80447-R08H-50
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反應性: Human  
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10161-T24-50
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反應性: Human  
應用 : ELISA  IHC-P  
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10161-RP02-50
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10161-RP02-100
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反應性: Human  
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    10161-RP03-50
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    反應性: Human  
    應用 : FCM  
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    10161-MM04-50
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    反應性: Human  
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      反應性: Human  
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        反應性: Human  
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          10161-MM02-50
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          反應性: Human  
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            10161-R029-50
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            反應性: Human  
            應用 : FCM  
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            10161-MM04-F-25
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            反應性: Human  
            應用 : ELISA  
              10161-R108-50
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              反應性: Mouse  
              應用 : ELISA  
                50059-R220-50
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                反應性: Mouse  
                應用 : ELISA  
                  50059-RP02-50
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                  反應性: Mouse  
                  應用 : ELISA  
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                  50059-RP01-400
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                  50059-RP01-100
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                  反應性: Rat  
                  應用 : ELISA  
                    80447-RP01-400
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                    80447-RP01-100
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                    100 µg 
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                    反應性: Rat  
                    應用 : ELISA  
                      80447-T16-50
                      80447-T16-200
                      80447-T16-100
                      50 µg 
                      200 µg 
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                      MCSF Receptor/CSF1R/CD115 cdna-clone 研究背景

                      M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

                       MCSF Receptor/CSF1R/CD115 cdna-clone 參考資料
                    • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
                    • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
                    • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
                    • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
                    • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
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