Chemokine Family

Overview of Chemokine Family

Chemokines are the largest family of cytokines in human immunophysiology. These proteins are defined by four invariant cysteines and are categorized based on the sequence around the first two cysteines, which leads to two major and two minor subfamilies.

Chemokine agonists that have an intervening amino acid between the first two cysteines are subclassified as CXC or α-chemokines. If the first two cysteines are adjacent to each other, the chemokines are known as CC or β-chemokines. Another subfamily, the CX3C or the γ -chemokine, possesses only one protein in its category and is defined by three intervening residues between the first two cysteines. The CX3C chemokine is unusual because it is part of a cell surface receptor. One of two exceptions to the four-cysteine paradigm is the C or δ-chemokine, in which the polypeptide has only two of the four cysteines. The same gene encodes both members of this subfamily, which share different splice sites and differ in only two amino acids. There are also a few chemokines from the β-chemokine subfamily that possess six cysteines, all of which are also disulfide bonded.

CC Chemokine & Receptor

CC Chemokine Ligand

CCL1 / I-309 / TCA-3 CCL12 / MCP-5* CCL21 / 6Ckine
CCL2 / MCP-1* CCL13 / MCP-4* CCL22 / MDC*
CCL3/MIP-1 alpha CCL14 / HCC-1 / HCC-3 CCL23 / MIP-3 / MPIF-1*
CCL4 / MIP-1 beta* CCL15 / MIP-5 / MIP-1 delta CCL24 / Eotaxin-2 / MPIF-2*
CCL5 / RANTES CCL16 / HCC-4* CCL25 / TECK*
CCL6 / C10 CCL17 / TARC CCL26 / Eotaxin-3*
CCL7 / MCP-3 CCL18 / MIP-4 / PARC* CCL27 / CTACK*
CCL8 / MCP-2 CCL19 / MIP-3 beta* CCL28*
CCL11 / Eotaxin* CCL20 / MIP-3 alpha*  

CC Chemokine Receptor

CCR1 CCR2 CCR3
CCR4 CCR5 CCR6
CCR7 CCR8 CCRL1*
FAM19A2 / TAFA2*    

CXC Chemokine & Receptor

CXC Chemokine Ligand

CXCL1 CXCL8 CXCL15 / Lungkine*
CXCL2 / MIP-2 CXCL9 / MIG CXCL16
CXCL3* CXCL10* CXCL17*
CXCL4 / PF4 CXCL11* XCL1
CXCL5* CXCL12 / SDF1b XCL2
CXCL6* CXCL13 / BCA-1  
CXCL7* CXCL14 / BRAK*  

CXC Chemokine Receptor

CXCR1 / CD128 / IL-8RA* CXCR2 / CD128b / IL-8RB*

CX3C Chemokine & Receptor

CX3C Chemokine Ligand

CX3CL1 / Fractalkine

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References

Chemokine Receptor Information

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Cytokine Family
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